Ethan Ashby

Ethan Ashby

Biostatistics PhD Student, University of Washington

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A list of all the posts and pages found on the site. For you robots out there is an XML version available for digesting as well.

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Posts

Time-varying VE Paper wins ASA Early in Career Award

less than 1 minute read

Published:

My paper, “Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial”, was selected as an Early in Career Paper Award Winner by the American Statistical Association (ASA) in 2026. Many thanks to all my collaborators, and I am excited to attend the JSM meeting in August 2026 to present my work!

Time-varying VE paper wins Student Distinguished Paper Award at ENAR

less than 1 minute read

Published:

My paper, “Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial”, was selected as a Distinguished Student Paper Award Winner by the Eastern North American Region (ENAR) of the International Biometrics Society (IBS) in 2026. Many thanks to all my collaborators, and I am excited to attend the ENAR Spring meeting in March 2026 to present my work!

misc

portfolio

publications

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms

Published in MSphere, 2022

Cut&Run data analysis demonstrates Bdf3 protein occupancy changes at different sites on the T. brucei genome.

Recommended citation: Ashby, Ethan, et al. (2022). "Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms." MSphere . 7(3). https://journals.asm.org/doi/full/10.1128/msphere.00023-22

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

Published in Microbiology Spectrum, 2023

Investigating time-course transcriptional response to Bdf3 inhibition in the parasite that causes sleeping sickness.

Recommended citation: Ashby, Ethan C. (2023). "Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome." Microbiology Spectrum. 1(1). https://journals.asm.org/doi/full/10.1128/spectrum.00147-23

Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants

Published in Statistics in Medicine, 2025

Adjustment for off-target endpoints can improve the efficiency of early-phase randomized trials.

Recommended citation: Ashby, Ethan, et al. (2025). "Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants." Statistics in Medicine. https://onlinelibrary.wiley.com/doi/10.1002/sim.70142

Validating and Leveraging Non-SARS-CoV-2 Respiratory Infection as a Negative Control Outcome in a Phase 3 COVID-19 Vaccine Trial with Extended Observational Follow-Up

Published in American Journal of Epidemiology, 2025

Irrelevant infection endpoints confirmed as a valid negative control for COVID-19 and are leveraged to detect bias in hazard-based, time-varying vaccine efficacy estimates.

Recommended citation: Ashby, Ethan, et al. (2025). "Validating and Leveraging Non-SARS-CoV-2 Respiratory Infection as a Negative Control Outcome in a Phase 3 COVID-19 Vaccine Trial with Extended Observational Follow-Up." American Journal of Epidemiology. https://academic-oup-com.offcampus.lib.washington.edu/aje/advance-article/doi/10.1093/aje/kwaf176/8239036?utm_source=advanceaccess&utm_campaign=aje&utm_medium=email

Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial

Published in ArXiv, 2025

Time-varying hazard ratios are popular tools to evaluate how vaccine effects vary over time. We explore how to use negative control infections to remove inherent bias in these estimates.

Recommended citation: Ashby, Ethan, et al. (2025). "Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial." ArXiv. https://arxiv.org/abs/2511.15099

talks

teaching

Theory Exam Study Materials

Teaching materials, , 1900

Here are my study materials that I created in preparation for UW Biostat’s 2nd year theory exam! Hope it is useful to folks as they prepare for their own exams!