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Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms

Published in MSphere, 2022

Cut&Run data analysis demonstrates Bdf3 protein occupancy changes at different sites on the T. brucei genome.

Recommended citation: Ashby, Ethan, et al. (2022). "Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms." MSphere . 7(3). https://journals.asm.org/doi/full/10.1128/msphere.00023-22

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

Published in Microbiology Spectrum, 2023

Investigating time-course transcriptional response to Bdf3 inhibition in the parasite that causes sleeping sickness.

Recommended citation: Ashby, Ethan C. (2023). "Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome." Microbiology Spectrum. 1(1). https://journals.asm.org/doi/full/10.1128/spectrum.00147-23

Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants

Published in arXiv, 2024

Adjustment for off-target endpoints can improve the efficiency of early-phase randomized trials.

Recommended citation: Ashby, Ethan, et al. (2024). "Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants." ArXiv. https://arxiv.org/abs/2410.08078

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Theory Exam Study Materials

Teaching materials, , 1900

Here are my study materials that I created in preparation for UW Biostat’s 2nd year theory exam! Hope it is useful to folks as they prepare for their own exams!