New preprint on arXiv!

My paper, “Improving the efficiency of infectious disease prevention trials using negative control outcome event times”, is now available on arXiv. We investigate how adjusting for negative control infection times can improve the efficiency of prevention efficacy estimates against a target infection time through overlapping exposure mechanisms. The work draws heavily on semiparametric theory for coarsened/censored data models and also includes some nice connections to classical survival analysis results such as the redistribute-to-the-right algorithm. Focusing on the case of a HIV prevention study, we show that adjusting for other sexually transmitted infection times could improve precision by 27% whereas adjusting for the best available baseline covariates led to negligible improvements. You can find the manuscript linked here.